MIT Open Access Articles: Recent submissions
Now showing items 223-225 of 55604
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Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols
(American Chemical Society, 2024-06-26)We report a general and functional-group-tolerant method for the Cu-catalyzed amination of base-sensitive aryl bromides including substrates possessing acidic functional groups and small five-membered heteroarenes. The ... -
Copper-Catalyzed Amination of Aryl Chlorides under Mild Reaction Conditions
(American Chemical Society, 2024-09-16)We report a mild method for the copper-catalyzed amination of aryl chlorides. Key to the success of the method was the use of highly sterically encumbered <i>N</i><sup>1</sup>,<i>N</i><sup>2</sup>-diaryl diamine ligands ... -
Development of a Deactivation-Resistant Dialkylbiarylphosphine Ligand for Pd-Catalyzed Arylation of Secondary Amines
(American Chemical Society, 2024-09-17)Despite the prevalence of N-heteroarenes in small-molecule pharmaceuticals, Pd-catalyzed C-N cross-coupling reactions of aryl halides and amines containing these rings remain challenging due to their ability to displace ...
