MIT Open Access Articles

Human Brain Organoids: A New Model to Study Cryptococcus neoformans Neurotropism

Harding, Alfred T.; Gehrke, Lee; Vyas, Jatin M.; Harding, Hannah Brown (Multidisciplinary Digital Publishing Institute, 2025-07-19)

With the rise in immunocompromised individuals and patients with immune-related comorbidities such as COVID-19, the rate of fungal infections is growing. This increase, along with the current plateau in antifungal drug ...
Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19

Richardson, Edward; Mo, Clifton C.; Calabretta, Eleonora; Corrado, Francesco; Kocoglu, Mehmet H.; e.a. (Multidisciplinary Digital Publishing Institute, 2025-07-14)

Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad ...
Beyond the Counter: A Systemic Mapping of Nanostore Identities in Traditional, Informal Retail Through Multi-Dimensional Archetypes

Salinas-Navarro, David Ernesto; Vilalta-Perdomo, Eliseo; Mejía-Argueta, Christopher (Multidisciplinary Digital Publishing Institute, 2025-07-05)

This study examines the identity of nanostores—micro, independent grocery retailers—through a systemic, stakeholder-informed lens to promote their survivability and competitiveness. Moving beyond traditional operational ...