MIT Open Access Articles

Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants

Lim, Sing Mei; Cheng, Hoi Lok; Jia, Huan; Kongsuphol, Patthara; D/O Shunmuganathan, Bhuvaneshwari; e.a. (Wiley, 2022-01-22)

There is clinical need for a quantifiable point-of-care (PoC) SARS-CoV-2 neutralizing antibody (nAb) test that is adaptable with the pandemic's changing landscape. Here, we present a rapid and semi-quantitative nAb test ...
Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 Variants

Cheng, Hoi Lok; Lim, Sing Mei; Jia, Huan; Chen, Ming Wei; Ng, Say Yong; e.a. (American Society for Microbiology, 2022-09-07)

As the COVID-19 pandemic continues, countries around the world are switching toward vaccinations and boosters to combat the pandemic. However, waning immunity against SARS-CoV-2 wild-type (WT) and variants have been widely ...
Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

Sheen, Allison; Agarwal, Yash; Cheah, Keith M; Cowles, Sarah C; Stinson, Jordan A; e.a. (Elsevier BV, 2023-08)

Catalase is an antioxidant enzyme that catalyzes the rapid conversion of hydrogen peroxide to water and oxygen. Use of catalase as a cancer therapeutic has been proposed to reduce oxidative stress and hypoxia in the tumor ...