MIT Open Access Articles: Recent submissions

Now showing items 1-3 of 54366

    • The Future of Drug Delivery 

      Gao, Jingjing; Karp, Jeffrey M; Langer, Robert; Joshi, Nitin (American Chemical Society, 2023-01-24)
      Drug delivery technologies have been proven to improve treatment outcomes in many ways, including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance, and enabling entirely new medical treatments. ...

    • Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases 

      Chauhan, Vikash P; Sharp, Phillip A; Langer, Robert (Proceedings of the National Academy of Sciences, 2023-03-07)
      CRISPR-Cas9 introduces targeted DNA breaks that engage competing DNA repair pathways, producing a spectrum of imprecise insertion/deletion mutations (indels) and precise templated mutations (precise edits). The relative ...

    • Hydrogels for RNA delivery 

      Zhong, Ruibo; Talebian, Sepehr; Mendes, Bárbara B; Wallace, Gordon; Langer, Robert; e.a. (Springer Science and Business Media LLC, 2023-03-20)
      RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success ...