MIT Open Access Articles: Recent submissions
Now showing items 1-3 of 54366
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The Future of Drug Delivery
(American Chemical Society, 2023-01-24)Drug delivery technologies have been proven to improve treatment outcomes in many ways, including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance, and enabling entirely new medical treatments. ... -
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
(Proceedings of the National Academy of Sciences, 2023-03-07)CRISPR-Cas9 introduces targeted DNA breaks that engage competing DNA repair pathways, producing a spectrum of imprecise insertion/deletion mutations (indels) and precise templated mutations (precise edits). The relative ... -
Hydrogels for RNA delivery
(Springer Science and Business Media LLC, 2023-03-20)RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success ...