MIT Open Access Articles: Recent submissions
Now showing items 4-6 of 54349
-
Combinatorial development of nebulized mRNA delivery formulations for the lungs
(Springer Science and Business Media LLC, 2023-11-20)Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However, nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including stability during nebulization and penetration ... -
Nanoparticle‐Mediated Delivery of Anti‐PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation
(Wiley, 2024-02-22)Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified in genome wide association studies and ... -
CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells
(Springer Science and Business Media LLC, 2024-10-16)CRISPR–Cas9 genome editing technology is a promising tool for genetically engineering immune cells and modulating immune systems. Although ex vivo genome editing of immune cells has reached clinical trials, in vivo application ...
