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Readings

A sessionwise listing of readings is included in the table below.

Required Text

[Golan]: Buy at Amazon Golan, David E., Editor-in-chief; Armen H. Tashjian, Deputy Editor; Ehrin J. Armstrong, et al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Baltimore, MD: Lippincott Williams & Wilkins, 2005. ISBN: 9780781746786.

Recommended Text

[C&D]: Buy at Amazon Klaassen, Curtis D., ed. Casarett and Doull's Toxicology: The Basic Science of Poisons. 6th ed. New York, NY: McGraw-Hill Medical Pub Division, 2001. ISBN: 9780071347211.

Additional Useful Resources

Buy at Amazon Guyton, Arthur C., and John E. Hall. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier Saunders, 2005. ISBN: 9780721602400.

Buy at Amazon Vander, Arthur, James Sherman, and Dorothy Luciano. Human Physiology: The Mechanisms of Body Function. 8th ed. Boston, MA: McGraw-Hill, 2001. ISBN: 9780072554991.

Buy at Amazon Gilman, A. G., T. W. Rall, A. S. Nies, and P. Taylor, eds. The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill, 2000. ISBN: 9780080402963.

Buy at Amazon Junqueira, Luiz Carlos, José Carneiro, and Robert O. Kelley. Basic Histology. 9th ed. New York, NY: McGraw-Hill, 1998. ISBN: 9780838505908.

Buy at Amazon Bloom, William, and Don W. Fawcett. A Textbook of Histology. 10th ed. Philadelphia, PA: W.B. Saunders, 1975. ISBN: 9780721617572.

Readings by Session

LEC # TOPICS READINGS
1 Introduction and Principles  
2 Chemistry/Biochemistry Review  
3 Overview of Drug Development Golan. Chapters 48 and 51.
4 Uptake/Transport/Distribution of Drugs Golan. pp. 27-33.
5 Drug Transporters  
6 Bioethics Seminar  
7 Drug Transporters (cont.)  
8 Introduction to Drug Metabolism

Golan. Chapter 4.

C&D. Chapter 6.
9 Liver Lecture  
10 Drug Metabolism 2

Golan. Chapter 4.

C&D. Chapter 6.
11 Drug Metabolism 3

Golan. Chapter 4.

C&D. Chapter 6.
12 Drug Metabolism 4

Golan. Chapter 4.

C&D. Chapter 6.
13 Quiz Review  
14 Oxygen Radicals in Drug Toxicity  
15 Drug Toxicities Golan. Chapter 47.
16 Drug Toxicities (cont.) Golan. Chapter 47.
17 Bioethics Seminar  
18 Pharmacokinetics Golan. Chapter 3.
19 Pharmacokinetics (cont.)

Golan. Chapter 3.

Farris, F. F., et al. "Cisplatin Pharmacokinetics: Applications of a Physiological Model." Toxicol Lett 43, nos. 1-3 (October 1988): 117-37.

Kartalou, M., and J. M. Essigmann. "Recognition of Cisplatin Adducts by Cellular Proteins." Mutat Res 478, nos. 1-2 (July 1, 2001): 1-21.

Pinto, A. L., and S. J. Lippard. "Binding of the Antitumor Drug Cis-diamminedichloroplatinum(II) (Cisplatin) to DNA." Biochim Biophys Acta 780, no. 3 (1985): 167-80.
20 Receptors and Case Study - Omeprazole

Golan. Chapters 1, 2, and 44.

de Morais, S. M., et al. "The Major Genetic Defect Responsible for the Polymorphism of S-mephenytoin Metabolism in Humans." J Biol Chem 269, no. 22 (June 3, 1994): 15419-22.

Goldstein, J. A. "Clinical Relevance of Genetic Polymorphisms in the Human CYP2C Subfamily." Br J Clin Pharmacol 52, no. 4 (October 2001): 349-55.

Kendall, M. J. "Review Article: Esomeprazole - The First Proton Pump Inhibitor to be Developed as an Isomer." Aliment Pharmacol Ther 17, no. 1 (February 2003): 1-4.

Lindberg, P., et al. "Review Article: Esomeprazole - Enhanced Bio-availability, Specificity for the Proton Pump and Inhibition of Acid Secretion." Aliment Pharmacol Ther 17, no. 4 (February 15, 2003): 481-8.

———. "The Mechanism of Action of the Gastric Acid Secretion Inhibitor Omeprazole." J Med Chem 29, no. 8 (August 1986): 1327-9.

Sachs, G., et al. "The Pharmacology of the Gastric Acid Pump: The H+,K+ ATPase." Annu Rev Pharmacol Toxicol 35 (1995): 277-305.

Chang, M., et al. "Interphenotype Differences in Disposition and Effect on Gastrin Levels of Omeprazole - Suitability of Omeprazole as a probe for CYP2C19." BR J Clin Pharmacol 39, no. 5 (May 1995): 511-8.
21 Case Study - Omeprazole

Golan. Chapter 52.

Papers from Lecture 20.
22 Case Study - Omeprazole (cont.)

Golan. Chapter 52.

Papers from Lecture 20.
23 Case Study - Acetaminophen

Golan. Chapter 40.

Hogestatt, E. D., et al. "Conversion of Acetaminophen to the Bioactive N-acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System." J Biol Chem 280, no. 36 (September 9, 2005): 31405-12. Epub (June 29, 2005).

Zhang, J., et al. "Modulation of Acetaminophen-induced Hepatotoxicity by the Xenobiotic Receptor CAR." Science 298, no. 5592 (October 11, 2002): 422-4.

Sueyoshi, T., et al. "The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene." J Biol Chem 274, no. 10 (March 5, 1999): 6043-6.

Knight, T. R., et al. "Peroxynitrite is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione." J Pharmacol Exp Ther 303, no. 2 (November 2002): 468-75.
24 Case Study - Acetaminophen (cont.)

Golan. Chapter 40.

Papers from Lecture 23.
25 Case Study - Statins

Golan. Chapter 22.

Zipes, D. P., et al. "Rosuvastatin: An Independent Analysis of Risks and Benefits." MedGenMed 8, no. 73 (2006).

Alawi, A., et al. "The Safety of Rosuvastatin as used in Common Clinical Practice." Circulation 111 (2005): 3051-3057.
26 Case Study - Statins (cont.)

Golan. Chapter 22.

Papers from Lecture 25.
27 Drug Industry Seminar  
28 Case Study - Statins (cont.)

Golan. Chapter 22.

Papers from Lecture 25.
29 Student Presentations  
30 Quiz Review  
31 Student Presentations (cont.)