This is an archived course. A more recent version may be available at ocw.mit.edu.

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Calendar

PCD = Prof. Peter Dedon
SRT = Prof. Steven Tannenbaum

 

LEC # TOPICS LECTURERS KEY DATES
1 Introduction and Principles PCD  
2 Chemistry/Biochemistry Review    
3 Overview of Drug Development Guest: Dr. Robert Rubin Homework 1 due
4 Uptake/Transport/Distribution of Drugs PCD  
5 Drug Transporters Guest: Dr. Keith Hoffmaster Homework 2 due
6 Bioethics Seminar    
7 Drug Transporters (cont.) Guest: Dr. Keith Hoffmaster  
8 Introduction to Drug Metabolism SRT  
9 Liver Lecture   Project teams assigned
10 Drug Metabolism 2 SRT  
11 Drug Metabolism 3 Guest: Dr. Sean Harriman  
12 Drug Metabolism 4 Guest: Dr. Sean Harriman  
13 Quiz Review   Homework 3 due one day after Lec #13
  Quiz 1 SRT  
14 Oxygen Radicals in Drug Toxicity SRT  
15 Drug Toxicities SRT  
16 Drug Toxicities (cont.) SRT  
17 Bioethics Seminar    
18 Pharmacokinetics PCD

Project summaries due

Homework 4 due
19 Pharmacokinetics (cont.) PCD Homework 5 due
20 Receptors and Case Study - Omeprazole PCD  
21 Case Study - Omeprazole PCD  
22 Case Study - Omeprazole (cont.) PCD  
23 Case Study - Acetaminophen SRT  
24 Case Study - Acetaminophen (cont.) SRT  
25 Case Study - Statins SRT/PCD Presentation schedule ready
26 Case Study - Statins (cont.) SRT/PCD Papers due
27 Drug Industry Seminar Guest: Mark Trusheim (Massachusetts Biotech Council)  
28 Case Study - Statins (cont.) SRT/PCD  
29 Student Presentations    
30 Quiz Review    
31 Student Presentations (cont.)    
  Quiz 2