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Spectroscopic study of the acetylene species
(Massachusetts Institute of Technology, 2003)
This thesis describes recent spectroscopic studies of acetylene and its HCCD isotopomer. Three different kinds of experiments have been performed: Laser-Induced Fluorescence (LIF), Dispersed Fluorescence (DF), and Stimulated ...
Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug
(Massachusetts Institute of Technology, 2004)
(cont.) with recombinant material. The in vitro system established in this study will facilitate the investigation of platinum-DNA damage by DNA repair processes and help elucidate the role of specific post-translational ...
Solid-state NMR investigations of the bacteriorhodopsin photocycle
(Massachusetts Institute of Technology, 2002)
Bacteriorhodopsin (bR) is a heptahelical integral membrane protein with a retinylidene prosthetic group from H. salinarum. The protein creates a proton gradient across the cell membrane by harvesting light energy. Proton ...
Applications of C₂-symmetric bis(azaferrocenes) in asymmetric copper-catalyzed reactions
(Massachusetts Institute of Technology, 2002)
Based on a strategy developed in our group for the desymmetrization of planar heterocycles, we have designed, synthesized, and resolved a number of bidentate, C2-symmetric planar-chiral bis(azaferrocenes) that bear a ...
Advances in non-heme diiron modeling chemistry : developing functional protein mimics through ligand design and understanding dioxygen activation
(Massachusetts Institute of Technology, 2011)
Chapter 1 A comprehensive review of diiron modeling in the Lippard group over the past thirty years is presented. This account describes the different strategies employed to prepare biomimetic complexes of non-heme diiron ...
Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
(Massachusetts Institute of Technology, 2005)
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Saccharomyces cerevisiae RNR is a class I RNR composed of a dimeric large subunit (RI), containing the active site and ...
Distal hydrogen-bonding effects and cofacial bimetallic salen architectures for oxygen activation chemistry
(Massachusetts Institute of Technology, 2007)
Two distinct structural scaffolds elaborated from Schiff-base macrocycles were designed to study the proton-coupled electron transfer chemistry of 0-0 bond forming and activation chemistry. The "Hangman" architecture is ...
Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines
(Massachusetts Institute of Technology, 2011)
I. N-Isopropylidene-N'-2-Nitrobenzenesulfonyl Hydrazine. A Reagent for Reduction of Alcohols via the Corresponding Monoalkyl Diazenes The development of a new reagent N-isopropylidene-N'-2-nitrobenzenesulfonyl hydrazine ...
Molecular design of conjugated polymers for the control of conformation, electronics and self-assembly
(Massachusetts Institute of Technology, 2008)
The design, synthesis and characterization of organic electronic materials, in particular luminescent conjugated polymers, with structural motifs that allow for the controlled modulation of their photophysical properties ...
Cyclopropene polymerization and enyne metathesis catalyzed by high oxidation state molybdenum alkylidenes
(Massachusetts Institute of Technology, 2008)
Chapter 1. An olefin metathesis reaction between Mo(NAr)(CHCMe2Ph)(OCMe(CF3)2)2 (Ar = 2,6diisopropylphenyl) and trans-i 1,4-divinylbenzene or trans, trans- 1,4-di-buta- 1,3-dienylbenzene (5) results in the formation of ...