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Regulation of microtubule attachment at the kinetochore and cell cortex
(Massachusetts Institute of Technology, 2016)
During mitosis, the cell divides in two, evenly distributing the genetic material and splitting the rest of cellular contents between the resulting daughter cells. This process is essential, rapid, and complex, requiring ...
Phenotypic heterogeneity and evolutionary games in microbial populations
(Massachusetts Institute of Technology, 2015)
One of the most interesting discoveries of the last decade is the surprising degree of phenotypic variability between individual cells in clonal microbial populations, even in identical environments. While some variation ...
Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
(Massachusetts Institute of Technology, 2016)
Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor ...
Adhesion-GPCRs in cancer progression and metastasis
(Massachusetts Institute of Technology, 2016)
Adhesion-GPCRs, a novel family of G protein-coupled receptors (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk ...
Population dynamics and diversity of Synechococcus on the New England shelf
(Massachusetts Institute of Technology, 2014)
Synechococcus is a ubiquitous marine primary producer. Our understanding of the factors that determine its abundance has been limited by available observational tools, which have not been able to resolve population dynamics ...
Coordinated regulation of glycolysis and the folate one-carbon cycle
(Massachusetts Institute of Technology, 2015)
Rapid cell proliferation is characteristic of many biological systems, including cancer, normal development, and immune responses. At a basic level, proliferation requires that a cell synthesize a new copy of itself, with ...
Genetic analysis of endoplasmic reticulum homeostasis during stress and infection of Caenorhabditis elegans
(Massachusetts Institute of Technology, 2018)
Animals experience intrinsic and extrinsic stressors throughout development and adulthood. To maintain cellular and organismal homeostasis, eukaryota and metazoa rely on conserved, integrated stress response pathways. ...
Mena 11a-isoform specific regulation of actin cytoskeleton organization and cell behavior
(Massachusetts Institute of Technology, 2016)
EnaNASP proteins are a conserved family of actin regulatory proteins that modulate cell motility and morphology by altering actin dynamics. Mena, an EnaNASP protein, is alternatively spliced, producing protein isoforms ...
Functions of the conserved ribosome-bound protein Lso2 in translation and physiology
(Massachusetts Institute of Technology, 2017)
The ribosome is a highly conserved macromolecular machine that carries out translation, the synthesis of proteins from mRNAs, in all domains of life. The core ribosome interacts with dozens of general translation factors ...
Insights into the consequences of chromosome gains and losses in S. cerevisiae
(Massachusetts Institute of Technology, 2016)
When cells divide, they must properly duplicate and segregate their genome to generate two identical daughter cells with faithful transmission of the genomic content. Errors in chromosome segregation lead to aneuploidy, a ...