MIT Open Access Articles: Recent submissions

Now showing items 88-90 of 54452

    • Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases 

      Chauhan, Vikash P; Sharp, Phillip A; Langer, Robert (Proceedings of the National Academy of Sciences, 2023-03-07)
      CRISPR-Cas9 introduces targeted DNA breaks that engage competing DNA repair pathways, producing a spectrum of imprecise insertion/deletion mutations (indels) and precise templated mutations (precise edits). The relative ...

    • Hydrogels for RNA delivery 

      Zhong, Ruibo; Talebian, Sepehr; Mendes, Bárbara B; Wallace, Gordon; Langer, Robert; e.a. (Springer Science and Business Media LLC, 2023-03-20)
      RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success ...

    • The Thermal Reactivity and Molecular Diversity of Particulate Organic Carbon in the Amazon River Mainstem 

      Rosengard, Sarah Z.; Mauro S. Moura, Jose; Spencer, Robert G. M.; Johnson, Carl; McNichol, Ann; e.a. (Wiley, 2025-06-18)
      The Amazon River mobilizes one of the largest fluxes of particulate organic carbon (POC) fromland to coastal ocean sediments, playing an important role in the long‐term sequestration of biospheric organiccarbon in the ...