MIT Open Access Articles: Recent submissions
Now showing items 502-504 of 55784
-
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
(Springer Science and Business Media LLC, 2023-08-09)Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality ... -
Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression
(American Association for Cancer Research, 2023-06-02)Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for approximately 225,000 deaths per year. Despite preclinical successes, most interventions have failed to extend patient survival by more ... -
Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue Sarcomas
(American Association for Cancer Research, 2023-06-01)Purpose: Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting their clinical potential despite potent antitumor effects. We ...
