MIT Open Access Articles: Recent submissions

Now showing items 46-48 of 55096

    • Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks 

      Lam, Felix H; Turanlı-Yıldız, Burcu; Liu, Dany; Resch, Michael G; Fink, Gerald R; e.a. (American Association for the Advancement of Science, 2021-06-25)
      Lignocellulosic biomass remains unharnessed for the production of renewable fuels and chemicals due to challenges in deconstruction and the toxicity its hydrolysates pose to fermentation microorganisms. Here, we show in ...

    • Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica 

      Ma, Yongshuo; Liu, Nian; Greisen, Per; Li, Jingbo; Qiao, Kangjian; e.a. (Springer Science and Business Media LLC, 2022-01-31)
      Substrate inhibition of enzymes can be a major obstacle to the production of valuable chemicals in engineered microorganisms. Here, we show substrate inhibition of lycopene cyclase as the main limitation in carotenoid ...

    • Isotope tracing in health and disease 

      Dong, Wentao; Rawat, Eshaan S; Stephanopoulos, Gregory; Abu-Remaileh, Monther (Elsevier BV, 2022-08)
      Biochemical characterization of metabolism provides molecular insights for understanding biology in health and disease. Over the past decades, metabolic perturbations have been implicated in cancer, neurodegeneration, and ...