MIT Open Access Articles: Recent submissions
Now showing items 118-120 of 55498
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Copper-Catalyzed Amination of Aryl Chlorides under Mild Reaction Conditions
(American Chemical Society, 2024-09-16)We report a mild method for the copper-catalyzed amination of aryl chlorides. Key to the success of the method was the use of highly sterically encumbered <i>N</i><sup>1</sup>,<i>N</i><sup>2</sup>-diaryl diamine ligands ... -
Development of a Deactivation-Resistant Dialkylbiarylphosphine Ligand for Pd-Catalyzed Arylation of Secondary Amines
(American Chemical Society, 2024-09-17)Despite the prevalence of N-heteroarenes in small-molecule pharmaceuticals, Pd-catalyzed C-N cross-coupling reactions of aryl halides and amines containing these rings remain challenging due to their ability to displace ... -
Kinetic Modeling Enables Understanding of Off-Cycle Processes in Pd-Catalyzed Amination of Five-Membered Heteroaryl Halides
(American Chemical Society, 2024-11-20)The mechanism of Pd-catalyzed amination of five-membered heteroaryl halides was investigated by integrating experimental kinetic analysis with kinetic modeling through predictive testing and likelihood ratio analysis, ...
