Browsing MIT Open Access Articles by Author "Iannacone, Matteo"
Now showing items 1-2 of 2
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Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release
Ilyinskii, Petr O.; Roy, Christopher J.; O'Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; e.a. (Elsevier, 2014-03)Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ... -
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
Chevrier, Nicolas; Mertins, Philipp; Artyomov, Maxim N.; Shalek, Alex K.; Iannacone, Matteo; e.a. (Elsevier, 2011-11)Deciphering the signaling networks that underlie normal and disease processes remains a major challenge. Here, we report the discovery of signaling components involved in the Toll-like receptor (TLR) response of immune ...