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Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression

dc.contributor.authorKrismer, Konstantin
dc.contributor.authorBird, Molly A.
dc.contributor.authorVarmeh, Shohreh
dc.contributor.authorHandly, Erika D.
dc.contributor.authorGattinger, Anna
dc.contributor.authorBernwinkler, Thomas
dc.contributor.authorAnderson, Daniel A.
dc.contributor.authorHeinzel, Andreas
dc.contributor.authorJoughin, Brian A.
dc.contributor.authorKong, Yi Wen
dc.contributor.authorCannell, Ian G.
dc.contributor.authorYaffe, Michael B.
dc.date.accessioned2022-05-18T15:03:03Z
dc.date.available2021-10-27T19:58:16Z
dc.date.available2022-05-18T15:03:03Z
dc.date.issued2020-08
dc.date.submitted2020-06
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/1721.1/134134.2
dc.description.abstract© 2020 The Author(s) Krismer et al. present a computational approach to identify RNA-binding proteins (RBPs) that modulate post-transcriptional control of gene expression using RNA expression data as inputs. By applying this approach to publicly available patient datasets, they identify and experimentally confirm that the RBP hnRNPC contributes to chemotherapy resistance in lung cancer.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.celrep.2020.108064en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceScientific Reportsen_US
dc.titleTransite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expressionen_US
dc.typeArticleen_US
dc.contributor.departmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
dc.contributor.departmentCenter for Precision Cancer Medicine
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MIT
dc.contributor.departmentMassachusetts Institute of Technology. Synthetic Biology Center
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineering
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biology
dc.relation.journalCell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-08-04T15:09:52Z
dspace.orderedauthorsKrismer, K; Bird, MA; Varmeh, S; Handly, ED; Gattinger, A; Bernwinkler, T; Anderson, DA; Heinzel, A; Joughin, BA; Kong, YW; Cannell, IG; Yaffe, MBen_US
dspace.date.submission2021-08-04T15:09:58Z
mit.journal.volume32en_US
mit.journal.issue8en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work Neededen_US


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