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Biodegradable microfluidic scaffolds for vascular tissue engineering
(Massachusetts Institute of Technology, 2004)
This work describes the integration of novel microfabrication techniques for vascular tissue engineering applications in the context of a novel biodegradable elastomer. The field of tissue engineering and organ regeneration ...
A central composite design to investigate antibody fragment production by Pichia pastoris
(Massachusetts Institute of Technology, 2005)
This study aims to investigate the relationships between growth parameters (agitation, glycerol concentration, salt concentration) and responses (biomass, growth rate, protein expression), by a 3-factor-3-level central ...
Murine embryonic stem cells and hypoxia : growth kinetics, metabolism, and plating efficiency
(Massachusetts Institute of Technology, 2004)
There is reason to believe that embryonic stem cells would grow favorably in a hypoxic environment. These cells come from the pre-implantation embryo, whose native environment is the hypoxic mammalian reproductive tract. ...
Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions
(Massachusetts Institute of Technology, 2004)
Although embryonic stem (ES) cells and their pluripotent capability have been elucidated for decades, little study has been done on obtaining the pluripotency profile of ES cells in the incipient stages of differentiation. ...
Use of gene expression to characterize heterogeneous liver cell populations
(Massachusetts Institute of Technology, 2004)
Non-parenchymal cells (NPC's) are integral to recreate the native hepatic microenvironment and necessary to maintain in vivo liver function. A variety of in vitro culture systems have been developed to address different ...
EMG control of prosthetic ankle plantar flexion
(Massachusetts Institute of Technology, 2011)
Similar to biological human ankle, today's commercially available powered ankle-foot prostheses can vary impedance and deliver net positive ankle work. These commercially available prostheses are intrinsically controlled. ...
Characterization of self-assembling peptide nanofibers of KLD12 and RID 12
(Massachusetts Institute of Technology, 2004)
Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and ...
Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording
(Massachusetts Institute of Technology, 2004)
(cont.) electrodes.
Optimization of cell adhesion environments for a liver cell bioreactor
(Massachusetts Institute of Technology, 2006)
The MilliF bioreactor offers great potential for the formation of i vivo-like liver tissue outside the body, making it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an ...
Using machine learning to increase the predictive value of humanized mouse models for the human immune response to YFV-17D
(Massachusetts Institute of Technology, 2021-06)
Despite their utility as models for human systems, intrinsic differences between mouse and human biology limit direct translation of findings. Immunocompromised mice have been engrafted with functional human immune system ...