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A kinetic approach for the estimation of intracellular concentrations of nitrosative species in cells challenged by nitric oxide
(Massachusetts Institute of Technology, 2013)
Taylor-Aris dispersion in microfluidic networks
(Massachusetts Institute of Technology, 2002)
This thesis constitutes the development and application of a theory for the lumped parameter, convective-diffusive-reactive transport of individual, non-interacting Brownian solute particles ("macromolecules") moving within ...
Electrostatic and affinity enhancements of protein partitioning in two-phase aqueous micellar systems
(Massachusetts Institute of Technology, 2005)
This thesis was motivated by the practical need to develop a scalable and cost-effective separation method for low-cost, high-volume protein products. This unmet challenge can potentially be addressed by extraction in ...
A new class of photoresponsive surfactants
(Massachusetts Institute of Technology, 2005)
In this thesis, a new class of nonionic, photoresponsive surfactants consisting of a polar di(ethylene oxide) head group attached to an alkyl spacer of between two and eight methylene groups, coupled through an ether linkage ...
An error-controlled adaptive chemistry method for reacting flow simulations
(Massachusetts Institute of Technology, 2006)
Many technologically important processes in the chemical and mechanical industries involve coupled interactions of heat and mass transfer with chemical reactions - e.g. commercial burners, gas turbines, internal combustion ...
Developing fundamentally based models for autoignition
(Massachusetts Institute of Technology, 2005)
There is renewed interest in autoignition, especially due to the recent development of the homogenous charge compression ignition (HCCI) engine, highly promising with its low Nox and particulate emissions and high efficiency. ...
Origin, evolution, and control of sidewall line edge roughness transfer during plasma etching
(Massachusetts Institute of Technology, 2005)
(cont.) micromasking. Porous films seem especially prone, perhaps due to polymer diffusion into the pore structure. Control of polymerization during the etch through the use of lower-polymerizing fluorocarbons or the ...
Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
(Massachusetts Institute of Technology, 2007)
Most embryonic stem (ES) cell research has been performed using a gas-phase oxygen partial pressure (pO2gas) of 142 mmHg, whereas embryonic cells in early development are exposed to cellular pO2 (pO2cell) values of about ...
Permeability studies in biomimetic glycosaminoglycan-hydrogel membranes
(Massachusetts Institute of Technology, 2008)
The rates of water and solute transport tend to be lower in fibrous materials than in bulk solution. This phenomenon of "hindered transport" is caused by steric, hydrodynamic, and electrostatic interactions between the ...
Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
(Massachusetts Institute of Technology, 2007)
Assays that predict toxicity are an essential part of drug development and there is a demand for efficient models to better predict human responses. The in vivo micronucleus (MN) assay is a robust toxicity test that assesses ...