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Analysis of microtububule morphogenesis in vivo
(Massachusetts Institute of Technology, 1996)
Isolation of GCN5 and ADA5 in a selection for transcriptional adaptors
(Massachusetts Institute of Technology, 1997)
Investigations of tetraspanin functions using large extracellular loops
(Massachusetts Institute of Technology, 2005)
This thesis describes our characterization of a specific tetraspanin domain: the large extracellular loop (LEL). Tetraspanins are involved in cellular migration, adhesion, and metastasis, sperm-egg fusion, and viral ...
Regulation of DNA replication and cellular responses to perturbations in replication in the bacterium Bacillus subtilis
(Massachusetts Institute of Technology, 2006)
When a cell grows and divides to give rise to genetically identical cells, the genome of the cell is duplicated prior to cell-division. The process of genomic duplication is called DNA replication, and is closely coordinated ...
Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
(Massachusetts Institute of Technology, 2007)
Alteration of mitotic gene function has recently been discovered to play a key role in tumor formation and cancer progression through the induction of chromosomal aberrations and genomic instability. Polo-like-kinase-1 is ...
Anc1 : a new player in the cellular response to DNA damage
(Massachusetts Institute of Technology, 2007)
The continuity of living organisms depends on their ability to protect their genomes from a constant assault by internal and external sources of damage. To this end, cells have developed a variety of mechanisms to avoid ...
Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
(Massachusetts Institute of Technology, 2008)
PDZK1 is a four PDZ-domain containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a ...
Towards an understanding of the role of COPII subunits in vesicle coat assembly
(Massachusetts Institute of Technology, 1997)
Functional antagonism of the RNA polymerase II holoenzyme by negative regulators
(Massachusetts Institute of Technology, 1997)
Identification of new functions for BRCT domains
(Massachusetts Institute of Technology, 2008)
Our lab identified the tandem BRCT domains of PTIP function as a DNA damage responsive phospho binding domain that recognizes proteins phosphorylated by ATM and ATR after DNA damage. The PTIP tandem BRCT domains are ...