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Biodegradable microfluidic scaffolds for vascular tissue engineering
(Massachusetts Institute of Technology, 2004)
This work describes the integration of novel microfabrication techniques for vascular tissue engineering applications in the context of a novel biodegradable elastomer. The field of tissue engineering and organ regeneration ...
A central composite design to investigate antibody fragment production by Pichia pastoris
(Massachusetts Institute of Technology, 2005)
This study aims to investigate the relationships between growth parameters (agitation, glycerol concentration, salt concentration) and responses (biomass, growth rate, protein expression), by a 3-factor-3-level central ...
Murine embryonic stem cells and hypoxia : growth kinetics, metabolism, and plating efficiency
(Massachusetts Institute of Technology, 2004)
There is reason to believe that embryonic stem cells would grow favorably in a hypoxic environment. These cells come from the pre-implantation embryo, whose native environment is the hypoxic mammalian reproductive tract. ...
Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions
(Massachusetts Institute of Technology, 2004)
Although embryonic stem (ES) cells and their pluripotent capability have been elucidated for decades, little study has been done on obtaining the pluripotency profile of ES cells in the incipient stages of differentiation. ...
Use of gene expression to characterize heterogeneous liver cell populations
(Massachusetts Institute of Technology, 2004)
Non-parenchymal cells (NPC's) are integral to recreate the native hepatic microenvironment and necessary to maintain in vivo liver function. A variety of in vitro culture systems have been developed to address different ...
Characterization of self-assembling peptide nanofibers of KLD12 and RID 12
(Massachusetts Institute of Technology, 2004)
Self-assembling peptides are a promising new area of research with usage in numerous areas, from tissue engineering to membrane protein biology. This work is to further study the characteristics of the peptides KLD12 and ...
Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording
(Massachusetts Institute of Technology, 2004)
(cont.) electrodes.
Optimization of cell adhesion environments for a liver cell bioreactor
(Massachusetts Institute of Technology, 2006)
The MilliF bioreactor offers great potential for the formation of i vivo-like liver tissue outside the body, making it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an ...
Investigating the role of calcium in the biomechanical response of neutrophils to mechanical deformation experienced in the pulmonary capillaries
(Massachusetts Institute of Technology, 2006)
Neutrophils in the pulmonary microcirculation are subjected to mechanical deformation while traveling through capillaries of sizes much smaller than the mean neutrophil diameter. This deformation has been shown to result ...
Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
(Massachusetts Institute of Technology, 2006)
While many have explored how vascular processes alter gap junction communication and composition few have analyzed the role of specific gap junction connexin proteins in regulating cellular communication and wound healing. ...