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Design and in vitro development of resorbable urologic drug delivery device
(Massachusetts Institute of Technology, 2008)
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous ...
Multi-scale analysis of cardiac myoarchitecture
(Massachusetts Institute of Technology, 2008)
The distribution and generation of force within the myocardium during normal contractility is dictated by the tissue's underlying 3D myoarchitecture. The presence of disordered myoarchitecture may in turn constitute the ...
Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex
(Massachusetts Institute of Technology, 2008)
One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 and site 2, although it is unclear how asymmetry affects receptor activation and signaling. Here we report the ...