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PHF6 is a novel regulator of B-cell identity in acute lymphoblastic leukemia
(Massachusetts Institute of Technology, 2016)
Mutations in the zinc finger gene PHF6 are seen in approximately 20% of adult T-cell acute lymphoblastic leukemias and 3% of adult acute myeloid leukemias. The notable absence of PHF6 mutations in B-cell lineage malignancies ...
Ciliate micrograzer dynamics of the New England shelf
(Massachusetts Institute of Technology, 2017)
Protists play important roles in grazing and nutrient recycling, but quantifying these roles has been hindered by difficulties in collecting, culturing, and observing these often-delicate cells. During long-term deployments ...
The Mitotic Exit Network detects spindle position and anaphase entry
(Massachusetts Institute of Technology, 2019)
The Mitotic Exit Network (MEN), an essential GTPase signal-transduction cascade, controls mitotic exit in budding yeast. The MEN protects genomic integrity by ensuring chromosome segregation is complete prior to cytokinesis. ...
Defining sources of nutrient limitation for tumors
(Massachusetts Institute of Technology, 2019)
Tumor growth requires that cancer cells accumulate sufficient biomass to grow and divide. To accomplish this, tumor cells must acquire various nutrients, and growth slows if these metabolites are not obtained in sufficient ...
Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
(Massachusetts Institute of Technology, 2019)
Lung adenocarcinoma (LUAD) remains the world's leading cause of cancer related mortality with an estimated two-hundred thousand new cases arising in 2019 in the United states alone. Molecular characterization of patient ...
Enzyme structure, function, and evolution in flavonoid biosynthesis
(Massachusetts Institute of Technology, 2019)
Plant specialized metabolism is a key evolutionary adaptation that has enabled plants to migrate from water onto land and subsequently spread throughout terrestrial environments. Flavonoids are one particularly important ...
Pattern formation and essential responses for regeneration in planarians
(Massachusetts Institute of Technology, 2019)
The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, patterning cues and a set of cellular and molecular responses collectively ...
Structural and biophysical characterization of membrane-coating proteins from the nuclear pore and the primary cilium
(Massachusetts Institute of Technology, 2016)
A hallmark of eukaryotes is an endomembrane system that spatially separates cellular processes into discrete compartments. Macromolecular transport between these compartments canonically involves the fission and fusion of ...
Targeting and function of mammalian microRNAs
(Massachusetts Institute of Technology, 2009)
In the span of a few short years, animal microRNAs have become recognized as broad regulators of gene expression, largely in part due to our improved understanding of how animal microRNAs recognize their targets. Crucial ...
Genetic technologies to engineer and understand the microbiome
(Massachusetts Institute of Technology, 2018)
The microbes that inhabit the human body are integral to human health and disease: from inflammatory bowel disease to allergy, metabolic syndrome to autism. Due to its high connectivity with human physiology, manipulation ...