Search
Now showing items 231-240 of 296
Trait-based modeling of larval dispersal in the Gulf of Maine
(Massachusetts Institute of Technology, 2017)
Population connectivity is a fundamental process that governs the spatial and temporal dynamics of marine ecosystems. For many marine species, population connectivity is driven by dispersal during a planktonic larval phase. ...
Investigation of Cdc45 function during helicase activation
(Massachusetts Institute of Technology, 2017)
Eukaryotic DNA replication requires the stepwise loading of Mcm2-7 helicase complexes at origins of replication. These loaded helicases need to be activated during DNA replication initiation to unwind the DNA double helix ...
Neoblast specialization during regeneration of the planarian S. mediterranea
(Massachusetts Institute of Technology, 2018)
Planarians are well known for their ability to regenerate an entire animal from small tissue fragments. Planarian regeneration requires a population of dividing cells called neoblasts that are distributed throughout the ...
Development of natural and engineered bacteriophages as antimicrobials
(Massachusetts Institute of Technology, 2018)
One of the major public health concerns of the modern day is the emergence and spread of extensively antibiotic-resistant pathogens. We have already seen the arrival of infections caused by bacteria resistant to all available ...
Choices in regeneration: position and fate
(Massachusetts Institute of Technology, 2020)
Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally ...
Molecular, cellular, and circuit analysis of C. elegans spitting behavior
(Massachusetts Institute of Technology, 2020)
To identify the neural and molecular substrates of animal behavior and understand the principles by which they function is a major goal in neurobiology. One simple system for such behavioral studies is the pharynx of the ...
A transduction analysis of phagechromosome relationship.
(Massachusetts Institute of Technology, 1965)
In vivo shRNA screen reveals PRMT5 as a key regulator in glioblastoma
(Massachusetts Institute of Technology, 2017)
Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains a largely intractable malignancy that carries an extremely poor prognosis. Large scale genomic analyses have greatly expanded our knowledge of ...
Optimal bioeconomic management of changing marine resources
(Massachusetts Institute of Technology, 2016)
Marine populations are increasingly subjected to changing conditions whether through harvest or through broad-scale habitat change. Historically, few models have accounted for such trends over time, and even fewer have ...
Investigating the role of neuroendocrine signaling in the regulation of sexually dimorphic behavior of C. elegans
(Massachusetts Institute of Technology, 2018)
Sexual dimorphisms are a fundamental feature of the nervous systems of diverse animal species and the identification and functional characterization of such features is critical to our understanding of differences in ...