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AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
(Massachusetts Institute of Technology, 2018)
Cancer is a disease of normal healthy cells that have accumulated genetic aberrations that contribute to uncontrolled cell divisions. Generally, cancer cells have acquired gain of function mutations in oncogenes that ...
PHF6 modulates the chromatin landscape in B-cell leukemia
(Massachusetts Institute of Technology, 2018)
Developmental and lineage plasticity have been observed in numerous malignancies, and have been correlated with tumor progression and drug resistance. However, little is known about the molecular mechanisms that enable ...
Evolutionary dynamics of the human gut microbiome
(Massachusetts Institute of Technology, 2019)
The composite members of the human gut microbiome encounter a myriad of selective pressures from the host environment and other microbial members in the ecosystem. Understanding the evolutionary dynamics of microbial species ...
Recessive lethal amber suppressors in yeast
(Massachusetts Institute of Technology, 1975)
Identification of novel proteins that regulate the amino acid-sensitive mTORC1 pathway
(Massachusetts Institute of Technology, 2016)
mTOR is a serine-threonine kinase that, as the catalytic subunit of mTORC1, promotes growth and anabolism. Due to its central role in metabolism, the local and systemic environment surrounding the cell tightly regulate ...
Determinants of translational efficiency in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2015)
The goal of this thesis is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages ...
Defining the ecological and physiological traits of phytoplankton across marine ecosystem
(Massachusetts Institute of Technology, 2016)
Marine phytoplankton are central players in the global carbon cycle, responsible for nearly half of global primary production. The identification of the factors controlling phytoplankton ecology, physiology, and, ultimately, ...
Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling
(Massachusetts Institute of Technology, 2018)
Protein-protein interactions are central to all biological processes. Designer reagents that selectively bind to proteins and inhibit their interactions can be used to probe protein interaction networks, discover druggable ...
Influences of nutrition and pathogenicity from a microbial diet on immunity and longevity in Caenorhabditis elegans
(Massachusetts Institute of Technology, 2018)
Interactions with the environment play a critical role in animal physiology and evolution. Animals alter their cellular functions and organismal behavior to maximize survival in a given setting, or make the decision to ...
Genetic and metabolomic analysis of how population density modulates neuroendocrine physiology of C. elegans
(Massachusetts Institute of Technology, 2019)
In nature, organisms are presented with ever-changing environmental stimuli that can be beneficial or detrimental. Distinguishing the critically important environmental cues from the insignificant ones is integral to the ...