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Now showing items 201-210 of 296
Alexandrium catenella cyst dynamics in a coastal embayment : temperature dependence of dormancy, germination, and bloom initiation
(Massachusetts Institute of Technology, 2017)
Blooms of the dinoflagellate Alexandrium catenella cause paralytic shellfish poisoning syndrome and present an expanding public health threat. They are inoculated through the germination of benthic cysts, a process regulated ...
Aneuploidy causes proteotoxic stress in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2014)
Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is only beginning to be understood. ...
The role of pyruvate kinase regulation in tumor growth and metabolism
(Massachusetts Institute of Technology, 2014)
Cancer is a disease of inappropriate cell proliferation, and central carbon metabolism is highly regulated to support the unique anabolic needs of proliferating cells. Pyruvate kinase, the enzyme catalyzing the final step ...
Genetic and biochemical interactions between the DNA replication initiator and a chromosome architecture protein in Bacillus subtilis
(Massachusetts Institute of Technology, 2014)
I described the co-association, in vitro interaction, and epistatic relationship between the DNA replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis. Using ChIP-seq, I characterized the ...
Impacts of mucins on microbial physiology and interactions
(Massachusetts Institute of Technology, 2015)
The human body is colonized by trillions of microbes known collectively as the microbiota. Many of these organisms inhabit mucosal surfaces, with most found in the large intestines, but many also dwell in the respiratory ...
Control of innervation-dependent expression of the acetylcholine receptor delta subunit gene
(Massachusetts Institute of Technology, 1993)
Insights into gene regulation by genome structure, phase separation and developmental signaling
(Massachusetts Institute of Technology, 2020)
Proper regulation of gene expression is essential to the developmental processes that give rise to hundreds of different cell types with unique cellular identities. Regulation of protein-coding and long non-coding RNA genes ...
Enhancers and phase separation in the control of gene expression
(Massachusetts Institute of Technology, 2020)
Gene regulation underlies the control of cell identity, development, and disease. Transcription of genes is regulated by DNA elements called enhancers, which are bound by transcription factors and coactivators, leading to ...
A deadly hug : contact-dependent killing by Caulobacter crescentus, via cell surface-associated glycine-zipper proteins
(Massachusetts Institute of Technology, 2017)
In the battle for resources within microbial communities, antagonistic interactions between bacterial species are often mediated by diffusible inhibitory compounds, which can be diffusible or delivered in a contact-dependent ...
Characterizing the landscape of aminoacyl-tRNA synthetase protein production in Bacillus subtilis
(Massachusetts Institute of Technology, 2020)
The phenotype of a cell is a consequence of both the identity of the genes in the genome and the magnitude of their expression into proteins. While the biochemical function of many proteins has been uncovered, for most it ...