Browsing Doctoral Theses by Title
Now showing items 19977-19996 of 22097
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T cell mediated combination immunotherapy
(Massachusetts Institute of Technology, 2016)Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the ... -
A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
(Massachusetts Institute of Technology, 1999)CDS+ T lymphocytes recognize short peptide fragments when bound to self-class I major histocompatibility proteins. On a mature lymphocyte, such recognition results in activation of the T cell. On an immature thymocyte, ... -
Tabletop coherent extreme ultraviolet and soft X-ray sources based on high harmonic generation
(Massachusetts Institute of Technology, 2014)High harmonic generation (HHG) is a fascinating strong-field physics phenomenon that occurs when a laser pulse with a moderate intensity interacts with atoms and partially ionizes the atoms. A series of harmonics are ... -
TACHYON : customizable program analysis via generic abstract interpretation
(Massachusetts Institute of Technology, 1999) -
Tachyon condensation in string field theory
(Massachusetts Institute of Technology, 2003)In this thesis, we present some results that strongly support Sen's conjectures on tachyon condensation on a bosonic D-brane. Our main tool of analysis is level truncated open bosonic string field theory We use level ... -
Tackling car-sharing service design problems at scale with high-resolution data : discrete simulation-based optimization approaches
(Massachusetts Institute of Technology, 2020)This thesis considers the design of two-way (i.e., round-trip) car-sharing services. The optimization problems are formulated as high-dimensional discrete simulation-based optimization (DSO) problems. Existing DSO algorithms ... -
Tackling Key Challenges to Guide Clinical Decisions in Cardiovascular Diseases
(Massachusetts Institute of Technology, 2022-09)Machine learning models in healthcare have been widely studied in a number of contexts ranging from clinical risk stratification to image-guided diagnosis and prognostication. Nevertheless, key challenges remain from both ... -
Tackling the bigger picture in computational drug design : theory, methods, and application to HIV-1 protease and erythropoietin systems
(Massachusetts Institute of Technology, 2007)This thesis addresses challenging aspects of drug design that require explicit consideration of more than a single drug-target interaction in an unchanging environment. In the first half, the common challenge of designing ... -
Tactile mapping of harsh, constrained environments, with an application to oil wells
(Massachusetts Institute of Technology, 2011)This work develops a practical approach to explore rough environments when time is critical. The harsh environmental conditions prevent the use of range, force/torque or tactile sensors. A representative case is the mapping ... -
Tactile sensing of shape : biomechanics of contact investigated using imaging and modeling
(Massachusetts Institute of Technology, 2006)The overall goal of this research effort is to improve the understanding of the biomechanics of skin as it pertains to human tactile sense. During touch, mechanoreceptors beneath the skin surface are mechanically loaded ... -
Tactile, spatial interfaces for computer-aided design : superimposing physical media and computation
(Massachusetts Institute of Technology, 2003)Computer-aided design (CAD) systems have become invaluable in three-dimensional creative design fields such as architecture and landscape architecture. However, these digital tools have not replaced the use of physical ... -
Tactual display of consonant voicing to supplement lipreading
(Massachusetts Institute of Technology, 2003)This research is concerned with the development of tactual displays to supplement the information available through lipreading. Because voicing carries a high informational load in speech and is not well transmitted through ... -
Tailoring charge to spin conversion in novel materials for efficient spintronics
(Massachusetts Institute of Technology, 2022-09)The charge-to-spin conversion efficiency is the crux of the future of spintronics and electronics as it enables the generation and employment of both spin and electric current in the same device. Usually, this conversion ... -
Tailoring Fluoride/Fluorine Bond Activity for High-Energy Li and Li-ion Batteries
(Massachusetts Institute of Technology, 2022-05)Extending the classes of reactions that underlie electrochemical energy storage systems is of fundamental and practical importance to improving mobility, autonomy, medical devices and electronics. Most of the cathode ... -
Tailoring hydrodynamics of non-wetting droplets with nano-engineered surfaces
(Massachusetts Institute of Technology, 2013)Considering that contacts between liquid and solid are ubiquitous in almost all energy processes, including steam turbines, oil pumping, condensers and boilers, the efficiency of energy transportation can be maximized such ... -
Tailoring Mechanical Properties and Porosity in Laser Powder Bed Fusion by Spatial Manipulation of Feedstock Composition
(Massachusetts Institute of Technology, 2023-02)Additive manufacturing (AM) is capable of forming complex geometries, can build custom products, and offers greater versatility than many conventional manufacturing processes. Metal AM has revolutionized the design and ... -
Tailoring wetting behavior at extremes
(Massachusetts Institute of Technology, 2019)In the classical understanding of liquid interactions with surfaces, liquid/surface chemistry dictates wetting behavior, requiring use of specific materials to achieve desired behavior. This restriction creates a number ... -
Taking shape : the path to myosin activation in the Drosophila ventral furrow
(Massachusetts Institute of Technology, 2018)Creating biological form requires the generation of forces to rearrange tissues, as well as the patterning and organizational control of those forces to create the correct shapes. Force generation by actomyosin networks ... -
A tale of coupled vibrations in solution told by coherent two-dimensional infrared spectroscopy
(Massachusetts Institute of Technology, 2004)Coherent two-dimensional infrared (2D IR) spectroscopy is used as a tool for investigating the molecular structure and dynamics of coupled vibrations in solution on a picosecond timescale. The strongly coupled asymmetric ... -
A tale of two arbs : essays on agency and financial institutions
(Massachusetts Institute of Technology, 2008)This thesis consists of two essays covering topics in the economics of financial institutions with an emphasis on certain types of potential agency problems. In particular, it investigates two radically different types of ...
