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1 |
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Overview of Course, Orientation to Current Approaches and Types of Molecularly Designed Biomaterials
Molecular Design and Synthesis of Biomaterials I: Biodegradable Polymeric Solids
- Chemistry and Physical Chemistry of Hydrolysis
- Links between Materials Structure and Hydrolysis Mechanisms
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Problem Set 1 Assigned |
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2 |
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- Theory of Solid Polymer Erosion
- Enzymatic Degradation of Materials
- In vivo Degradation of Solid Polymers
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3 |
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- Biologic Recognition in vivo
- Engineering Biological Recognition of Solid Polymers
- Application Focus
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4 |
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Controlled Release Devices from Solid Polymers
- Degradable Materials as Controlled Release Devices
- Physical Chemistry Principles in Delivering Small Molecues vs. Proteins
- Theory of Drug Release in Systems with Different Degradation Mechanisms
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Problem Set 1 Solution
Problem Set 2 Assigned
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5 |
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- Drug Delivery Systems: Microspheres, Macrolaminates, and Reservoir Devices
- Molecular Design Tailored Controlled Release Devices
- Devices with Complex Release Profiles and Delivery of Multiple Cargos
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Problem Set 2 Solution |
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6 |
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Degradable Polymers and Tissue Engineering
- Key Properties of Degradable Materials as Synthetic ECMs
- Scaffold Design for Tissue Engineering
- Combining Drug Delivery with Tissue Engineering
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Problem Set 3 Assigned |
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7 |
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Molecular Design and Synthesis of Biomaterials II: Hydrogels
- Hydrogel Structure
- Methods of Polymerization
- Phys chem. of Physical Gels
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8 |
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- Design of Hydrogels as Synthetic ECMs
- Formation of Injectable, Self-Gelling Systems
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Problem Set 3 Solution |
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9 |
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- Hydrogels as Controlled Release Materials
- Theory of Diffusion in Hydrogels
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10 |
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- Polyelectrolyte Hydrogels
- Theory of Polyelectrolyte Gels and Coacervates
- Encapsulation of Drugs and Proteins in Polyelectrolyte Gels
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11 |
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Molecular Design and Synthesis of Biomaterials III: Bioceramics and Biocomposites
- Molecular Structure of Bone and Targets for Biomimetic Approaches
- Bone as a Nanocomposite
- Synthetic Approaches to Bone Structure
- Remodeling of Bioceramics in vivo
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12 |
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- Theory and Approach to Synthetic Biomineralization
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13 |
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Exam I |
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Problem Set 4 Assigned |
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14 |
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- Synthetic Approaches to Bone Structure (continued)
- Biocomposites in Device Applications and Drug Delivery
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15 |
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Combining Biological and Synthetic Molecules
- Biological Engineering with Hybrid Molecules: Common Objectives
- Outline of General Methods
- Key Molecules for Introducing Biological Function to Synthetic Systems
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Problem Set 4 Solution
Problem Set 5 Assigned
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16 |
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- Antibody and Peptide Production and Utilization
- Recombinant Protein Technology
- Chemical Approaches for Hybrid Molecules
- Polymeric Pro-Drugs
- Covalent vs. Non-covalent Strategies
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17 |
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- Design of Materials with Immobilized or Limited-Mobility Signals
- Steric Interaction Issues in Design of Artificial Receptor-Ligand Systems
- Soluble Molecules as Part of Controlled Release Systems
- Liposomes, Polymerosomes, and Colloidosomes
- Targeted Drug Delivery
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Problem Set 5 Solution |
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18 |
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- Surface Patterning of Biomolecules
- Gene Delivery From Surfaces (L.Shea)
- Application of Hybrid Molecules to Biosensor Design
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19 |
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Exam II |
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20 |
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Stimuli-Responsive Biomaterials
- Classes of Responsive Biomaterials
- Stimuli Suitable for in vivo Devices: Physiological Stimuli and External Stimuli
- Ex vivo Responsive Devices
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21 |
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- Thermally-Responsive Devices
- Thermodynamics of Thermally - Sensitive Biomaterials, UCST vs. LCST Systems
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22 |
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- Ph-Sensitive Materials
- Anti-Tumor Devices Based on pH Sensitivity
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23 |
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- Bioelectronics: Drug Delivery Chips
- Photosensitive Biomaterials
- Photonic Systems, Core-Shell Structures, Quantum Dots as in vivo Diagnostics and Delivery Devices
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24 |
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- Integrated Devices and the Future of 'Smart' Biomaterials
- Devices that 'Sense and Respond'
- Application focus: Synthetic Gene Delivery Vectors
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25 |
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Exam III |
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26 |
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Course wrap-up |
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