Now showing items 109-111 of 65464

    • Noncovalent PROTAC Antibody Drug Conjugates 

      Krum, David (Massachusetts Institute of Technology, 2026-02)
      Proteolysis Targeting Chimeras (PROTACs) are a new class of heterobifunctional drugs that induce proximity between an E3 ligase and a given protein of interest (POI), causing the POI to be ubiquitinated and targeted for ...
    • Interpolation Methods in Random Optimization and Deep Learning 

      El Cheairi, Houssam (Massachusetts Institute of Technology, 2026-02)
      This thesis studies three problems in high-dimensional probability and statistics: (1) the densest subgraph problem in dense random graphs, where the goal is to estimate and recover the subgraph with the highest edge ...
    • Predictive Methods and Datasets for Thermodynamic and Kinetic Modeling of Ionic Solutes 

      Zheng, Jonathan (Massachusetts Institute of Technology, 2026-02)
      The ability to quantitatively describe ionization phenomena is essential to designing medicines, developing novel materials, and modeling the time-evolution of many relevant liquid-phase chemical systems. In liquid phase ...