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Temperature-jump 2D IR spectroscopy to study protein conformational dynamics
(Massachusetts Institute of Technology, 2012)
Temperature-jump (T-jump) two-dimensional infrared spectroscopy (2D IR) is developed, characterized, and applied to the study of protein folding and association. In solution, protein conformational changes span a wide range ...
Ligand variation in molybdenum imido alkylidene complexes : a synthetic, structural, and catalytic study
(Massachusetts Institute of Technology, 2012)
Chapter 1. A general introduction is given. Chapter 2. The biscarboxylate species, Mo(NR)(CHCMe 2Ph)(O 2CPh3)2 (R = 2,6-i-Pr2C6H3, 2,6- Me2C6H3, 2-t-BuC 6H4, or 1 -adamantyl) are compared to newly synthesized bis(terphen ...
Mechanistic studies of proton-coupled electron transfer in aminotyrosine- and fluorotyrosine- substituted class Ia Ribonucleotide reductase
(Massachusetts Institute of Technology, 2012)
Ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to 2'- deoxynucleotides in all organisms. The class Ia RNR from Escherichia coli is active as an a2p2 complex and utilizes an unprecedented mechanism ...
Ensemble methods in computational protein and ligand design : applications to the Fc[gamma] immunoglobulin, HIV-1 protease, and ketol-acid reductoisomerase systems
(Massachusetts Institute of Technology, 2012)
This thesis explores the use of ensemble, free energy models in the study and design of molecular, biochemical systems. We use physics based computational models to analyze the molecular basis of binding affinity in the ...
Synthesis and applications of materials and polymers containing graphenic and/or triptycene moities
(Massachusetts Institute of Technology, 2013)
In this thesis, molecular design is used to synthesize novel materials with specific properties. The materials presented herein are based on two motifs. In part I, new methods of functionalizing graphenic materials and the ...
Synthesis of trichoverrol B and studies towards the synthesis of the roridins
(Massachusetts Institute of Technology, 1984)
Support experiments to the pyrolysis/gas chromatographic/mass spectrometric analysis of the surface of Mars
(Massachusetts Institute of Technology, 1979)
Insight into the structure and function of empty class II major histocompatibility complexes
(Massachusetts Institute of Technology, 2004)
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at the cell surface for interaction with CD4+ T cells as part of the system by which the immune system surveys the body for signs of ...
Addition and recombination reactions of unsaturated radicals using a novel laser kinetics spectrometer
(Massachusetts Institute of Technology, 2008)
This thesis describes the construction of a novel, low-noise laser kinetics spectrometer. A quasi-CW (picosecond pulse), tunable Ti:Sapphire laser is used to detect various transient species in laser flash photolysis ...
Poly(ethylene glycol)-based open-channel blockers for the acetylcholine receptor : mechanistic and structure-function studies at the single-channel level
(Massachusetts Institute of Technology, 2009)
Ion channels are essential mediators in nervous signaling pathways. Because hyperactivation of ion channels can lead to pathological disorders such as congenital myasthenic syndromes and neurodegeneration, channel inhibitors ...