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Now showing items 501-510 of 510
Application of risk management frameworks to medical device production development
(Massachusetts Institute of Technology, 2019)
Effective risk management is critical when manufacturing medical products to avoid any potential impact to patients due to supply disruptions or quality excursions. As Flex LTD, an end-to-end manufacturing solutions provider, ...
Data-driven predictive modeling for cell line selection in biopharmaceutical production
(Massachusetts Institute of Technology, 2019)
A critical component of the biopharmaceutical development cycle is the selection of the cell line that will become the Master Cell Bank for product manufacturing for clinical and commercial use. This cell line selection ...
Predictive earthquake damage modeling for natural gas distribution infrastructure
(Massachusetts Institute of Technology, 2018)
The Pacific Gas and Electric Company (PG&E) operates and maintains 48,000 miles of natural gas pipeline, serving over 4.3 million customer accounts. Along with water, electric power, and transportation services, these ...
Oral drug delivery as an alternative to needle-based injection for large molecules : an assessment of the field & evaluation of high-priority technologies
(Massachusetts Institute of Technology, 2018)
Oral delivery of large molecules is widely considered the "holy grail" of drug delivery, but attempts to achieve this within the past century have been met with a lack of success, confounded by low bioavailability. Novel ...
Environmental sustainability assessment tool for factories
(Massachusetts Institute of Technology, 2016)
General interest and international regulations have begun to create a world in which consumers demand to know how their products are made and companies must provide that transparency. With over 15,000 suppliers, Li & Fung ...
A costing model to assess customer profitability within Li & Fung
(Massachusetts Institute of Technology, 2016)
As the leading consumer goods design, development, sourcing and logistics company, Li & Fung Limited (Li & Fung) supplies high-volume, time-sensitive consumer goods for global retailers and brands. One of Li & Fung's ...
Virtual pooling approximation using longest path network optimization
(Massachusetts Institute of Technology, 2018)
Abstract This thesis proposes a network swapping mechanism to approximate a virtual finished goods inventory pool under the constraint of fragmented commercial channel ownership. Globally, Caterpillar sells its product ...
Amazon UK transshipment stow process analysis through discrete event simulation
(Massachusetts Institute of Technology, 2016)
This thesis investigated Amazon's implementation of transshipment, the act of moving inventory between fulfillment centers to facilitate order fulfillment, inventory rebalancing, and operational cost reduction. The role ...
Project-based manufacturing : an approach for quote development
(Massachusetts Institute of Technology, 2020)
Project-based manufacturing presents unique challenges that highly automated and repetitive production lines do not face. Highly automated production lines do not have much variation in the types of products that are made, ...
Digital business model development and validation for real-time monitoring solution for electrical power transformers
(Massachusetts Institute of Technology, 2020)
Currently, the health of high-value power transformers is primarily evaluated by visual inspections, oil sample analysis conducted by a third-party lab, and measurements taken by a mechanic physically present at the ...