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Now showing items 281-287 of 287
Examining metabolic vulnerabilities for cancer therapy
(Massachusetts Institute of Technology, 2018)
Metabolic reprogramming is essential for cancer cells to balance energetics, maintain redox homeostasis, and synthesize biosynthetic precursors. Many chemotherapeutics that target metabolism are essential components of ...
Effects of the mobile genetic element ICEBs1 on bacterial host fitness
(Massachusetts Institute of Technology, 2020)
Mobile genetic elements drive bacterial evolution by mediating horizontal gene transfer and by carrying cargo genes that confer important traits to host cells. Traits provided by mobile genetic elements include antibiotic ...
Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
(Massachusetts Institute of Technology, 2014)
Given their regenerative capacity, the planarian Schmidtea mediterranea has emerged as a model system for the study of stem cell biology, tissue specification, and axis formation. Many aspects of the regenerative machinery ...
Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
(Massachusetts Institute of Technology, 2017)
The genetic study of the C. elegans dauer developmental decision has served as an experimental paradigm for understanding how environmental cues influence organismal physiology through evolutionarily conserved neuroendocrine ...
CRISPR-mediated interrogation of small cell lung cancer
(Massachusetts Institute of Technology, 2018)
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung carcinoma that remains among the most lethal of solid tumor malignancies. Despite decades of research, treatment outcomes for SCLC remain very poor, ...
Co-targeting among microRNAs is widespread and enriched in the brain
(Massachusetts Institute of Technology, 2019)
MicroRNAs (miRNAs) play roles in diverse developmental processes and cellular differentiation. Distinct miRNAs have hundreds to thousands of conserved binding sites in mRNAs, but typically exert only modest repression on ...
Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
(Massachusetts Institute of Technology, 2020)
Structural and functional plasticity induced by neuronal competition is a common feature of developing nervous systems. However, the rules governing how postsynaptic cells differentiate between presynaptic inputs are ...