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Generation and Measurement of Entangled Atomic Ensembles with an Optical Cavity
(Massachusetts Institute of Technology, 2015)
Atomic interferometers have a resolution limit set by the projection noise in measurements on ensembles of uncorrelated atoms. To overcome this classical limit and extend precision measurements into the quantum regime, we ...
Dynamic control of Escherichia coli central metabolism for improvement of glucaric acid production
(Massachusetts Institute of Technology, 2015)
Metabolic engineering strategies have enabled improvements in yield and titer for a variety of valuable small molecules produced in microorganisms. Past approaches have been focused on up- and downregulation of genes to ...
Integrated experimental and computational analysis of intercellular communication with application to endometriosis
(Massachusetts Institute of Technology, 2018)
Cell-cell communication is critically important to the function of the immune system, allowing a systems-level determination of the appropriate type of immune response to a perturbation. The immune system has at its disposal ...
Engineering nanostructured selective layers for reverse osmosis membranes
(Massachusetts Institute of Technology, 2015)
A major challenge to communities across the world in the next century will be ensuring millions have access to adequate freshwater resources. Studies from the UN World Health Organization indicate that over 1.1 billion ...
Simulation and control of dynamic directed self-assembly of nanostructures
(Massachusetts Institute of Technology, 2015)
Self-assembled nanoscale structures are the basis for various technological advancements in functional materials, sensors, and molecular circuits and factories. With significant progress in self-assembly of periodic ...
Fear and frustration : rising state perceptions of threats and opportunities
(Massachusetts Institute of Technology, 2015)
Do a dominant state's policies have a greater effect on a rising state's threat perceptions or its assessment of the dominant state's resolve? Existing theory, rooted in Jervis's spiral and deterrence models, contends that ...
The role of type I collagen heterotrimers and homotrimers in mechanical strength and collagen cleavage
(Massachusetts Institute of Technology, 2014)
Collagen is a crucial structural protein, formed through a hierarchical assembly of molecules, arranged in collagen fibrils, which constitutes the basis for larger-scale fibers. Normal type I collagen is a heterotrimer ...
Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
(Massachusetts Institute of Technology, 2016)
Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor ...
Broadband terahertz photonics
(Massachusetts Institute of Technology, 2014)
In recent years, quantum cascade lasers have emerged as mature semiconductor sources of light in the terahertz range, the frequency range spanning 1 to 10 THz. Though technological development has pushed their operating ...
Three essays on entrepreneurial quality
(Massachusetts Institute of Technology, 2017)
This dissertation introduces a new method to measure entrepreneurial quality and applies it to three questions of theoretical interest in entrepreneurship. The dissertation is presented in five chapters. Chapter 1 is an ...