Singapore-MIT Alliance (SMA): Recent submissions

Now showing items 295-297 of 554

    • Understanding Oxidative Instability of Protein Pharmaceuticals 

      Chu, Jhih-Wei; Yin, Jin; Wang, Daniel I.C.; Trout, Bernhardt L. (2004-01)
      Mechanism of oxidation of methionine residues in protein pharmaceuticals by hydrogen peroxide was investigated via ab initio calculations. Specifically, two reactions, hydrogen transfer of hydrogen peroxide to form water ...

    • Delivery of Etanidazole to Brain Tumor from PLGA Wafers 

      Tan, Wilson Hor Keong; Lee, Timothy; Wang, Chi-Hwa (2004-01)
      This paper presents the computer simulation results on the delivery of Etanidazole (radiosensitiser) to the brain tumor and examines several factors affecting the delivery. The simulation consists of a 3D model of tumor ...

    • Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System 

      Tian, Y.; Tam, Michael K. C.; Hatton, T. Alan; Bromberg, Lev (2004-01)
      Doxorubicin (DOX) and Pluronic-PAA interaction was investigated using isothermal titration calorimetry (ITC). DOX/polymer interaction is governed primarily by electrostatic interaction. The uptake of DOX results in the ...