| dc.contributor.author | Love, Kerry | |
| dc.coverage.temporal | Spring 2008 | |
| dc.date.accessioned | 2023-03-06T16:54:13Z | |
| dc.date.available | 2023-03-06T16:54:13Z | |
| dc.date.issued | 2008-06 | |
| dc.identifier | 7.344-Spring2008 | |
| dc.identifier.other | 7.344 | |
| dc.identifier.other | IMSCP-MD5-6321f8c1769ca121b1d6228e00b8a6f1 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/148328 | |
| dc.description.abstract | Directed evolution has been used to produce enzymes with many unique properties. The technique of directed evolution comprises two essential steps: mutagenesis of the gene encoding the enzyme to produce a library of variants, and selection of a particular variant based on its desirable catalytic properties. In this course we will examine what kinds of enzymes are worth evolving and the strategies used for library generation and enzyme selection. We will focus on those enzymes that are used in the synthesis of drugs and in biotechnological applications. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. | en |
| dc.language.iso | en-US | |
| dc.rights | This site (c) Massachusetts Institute of Technology 2023. Content within individual courses is (c) by the individual authors unless otherwise noted. The Massachusetts Institute of Technology is providing this Work (as defined below) under the terms of this Creative Commons public license ("CCPL" or "license") unless otherwise noted. The Work is protected by copyright and/or other applicable law. Any use of the work other than as authorized under this license is prohibited. By exercising any of the rights to the Work provided here, You (as defined below) accept and agree to be bound by the terms of this license. The Licensor, the Massachusetts Institute of Technology, grants You the rights contained here in consideration of Your acceptance of such terms and conditions. | en |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 Unported | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | * |
| dc.subject | evolution | en |
| dc.subject | biocatalyst | en |
| dc.subject | mutation | en |
| dc.subject | library | en |
| dc.subject | recombination | en |
| dc.subject | directed evolution | en |
| dc.subject | enzyme | en |
| dc.subject | point mutation | en |
| dc.subject | mutagenesis | en |
| dc.subject | DNA | en |
| dc.subject | evolution | en |
| dc.subject | gene | en |
| dc.subject | complementation | en |
| dc.subject | affinity | en |
| dc.subject | phage | en |
| dc.subject | ribosome display | en |
| dc.subject | yeast surface display | en |
| dc.subject | bacterial cell surface display | en |
| dc.subject | IVC | en |
| dc.subject | FACS | en |
| dc.subject | active site | en |
| dc.title | 7.344 Directed Evolution: Engineering Biocatalysts, Spring 2008 | en |
| dc.title.alternative | Directed Evolution: Engineering Biocatalysts | en |
| dc.type | Learning Object | |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | |
| dc.audience.educationlevel | Undergraduate | |
| dc.subject.cip | 261004 | en |
| dc.subject.cip | Toxicology | en |
| dc.date.updated | 2023-03-06T16:54:21Z | |
