Browsing by Title
Now showing items 37483-37502 of 143790
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A dynamo case study of Mercury, and the early orbital and thermal evolution of the Moon
(Massachusetts Institute of Technology, 2017)Mercury's magnetic field is characterized by its weak strength, spin-aligned axisymmetry and a large offset of the magnetic equator relative to Mercury's geographic equator. The combination of these features is difficult ... -
Dynamo: Handling Scientific Data Across Sites and Storage Media
(Springer International Publishing, 2021-04-12)Abstract Dynamo is a full-stack software solution for scientific data management. Dynamo’s architecture is modular, extensible, and customizable, making the software suitable for managing data in a wide range ... -
Dynast: Inclusive and efficient quantification of metabolically labeled transcripts in single cells
(Massachusetts Institute of Technology, 2022-09)Single cell RNA velocity, defined as the time derivative of gene expression, is a powerful concept that can predict the future transcriptional state of the cell. Traditionally, RNA velocity estimations relied on the ... -
Dynometrics : an innovative lactic acid measurement solution for endurance athletes
(Massachusetts Institute of Technology, 2015)Aspire is a company I co-founded along with John, PhD, in September 2014. Our mission is to be a breath of fresh air in the old-fashioned wearable sports technology market by leveraging the power of science and data to ... -
Dysbiosis is not an answer
(Nature Publishing Group, 2016-11)Dysbiosis, an imbalance in the microbiota, has been a major organizing concept in microbiome science. Here, we discuss how the balance concept, a holdover from prescientific thought, is irrelevant to — and may even distract ... -
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD
(Springer Science and Business Media LLC, 2020-03)Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood. Here we examined ... -
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD
(Springer Science and Business Media LLC, 2020-03)Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood. Here we examined ... -
Dysfunction of Rapid Neural Adaptation in Dyslexia
(Elsevier BV, 2016-12)Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit ... -
Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis
(John Wiley & Sons, Inc/Union for International Cancer Control, 2013-09)Although the influence of context-dependent endothelial cell (EC) regulation of vascular disease and repair is well-established, the privileged roles ECs play as paracrine regulators of tumor progression has only recently ... -
Dysfunctional tRNA reprogramming and codon-biased translation in cancer
(Elsevier BV, 2022)Many cancers hijack translation to increase the synthesis of tumor-driving proteins, the messenger mRNAs of which have specific codon usage patterns. Termed 'codon-biased translation' and originally identified in stress ... -
Dysprosium Iron Garnet Thin Films with Perpendicular Magnetic Anisotropy on Silicon
(Wiley, 2019-11-28) -
Dysprosium substituted Ce:YIG thin films with perpendicular magnetic anisotropy for silicon integrated optical isolator applications
(AIP Publishing, 2019-08)In this report, dysprosium substituted Ce[subscript 1]Y[subscript 2]Fe[subscript 5]O[subscript 12] (Ce:YIG) thin films (Dy:CeYIG) with perpendicular magnetic anisotropy (PMA) are successfully deposited on silicon and ... -
Dysregulated metabolism contributes to oncogenesis
(Elsevier, 2015-10)Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic rearrangement characterized by changes in metabolic pathways involved in energy ... -
Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis
(American Association for the Advancement of Science (AAAS), 2013-03)Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL), but the underlying mechanisms are unclear. We identified the guanine nucleotide exchange factor ... -
Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice
(National Academy of Sciences, 2012-04)The ability to quantitatively evaluate the impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease is a critical step in the pathway to development of an effective therapy ... -
Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice
(National Academy of Sciences, 2012-04)The ability to quantitatively evaluate the impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease is a critical step in the pathway to development of an effective therapy ... -
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder
(Nature Publishing Group, 2015-01)Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we hypothesized that microRNAs (miRNAs) might be of importance for ... -
Dysregulation of mRNA Localization and Translation in Genetic Disease
(Biomed Central Ltd., 2016-11)RNA-binding proteins (RBPs) acting at various steps in the post-transcriptional regulation of gene expression play crucial roles in neuronal development and synaptic plasticity. Genetic mutations affecting several RBPs and ... -
Dzyaloshinskii-Moriya Interaction and Local Exchange Variation in Rare-Earth Transition-Metal Ferrimagnets
(Massachusetts Institute of Technology, 2023-06)Spintronics utilizes the spin of electrons in addition to its charge to manipulate magnetism in thin films. Research in spintronics has the potential to usher in a new wave of technologies, particularly in next-generation ...
