Browsing by Author "Naba, Alexandra"
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7.345 Vascular Development in Life, Disease and Cancer Medicine, Fall 2009
Naba, Alexandra; Turner, Christopher (2009-12)The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will ... -
Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
Clauser, Karl R.; Naba, Alexandra; Hynes, Richard O. (MyJoVE Corporation, 2015-07)The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins that provides biophysical and biochemical cues that are major regulators of cell proliferation, survival, migration, etc. The ECM plays important ... -
The extracellular matrix: Tools and insights for the “omics” era
Clauser, Karl R.; Carr, Steven A.; Naba, Alexandra; Ding, Huiming; Whittaker, Charles A.; e.a. (Elsevier, 2015-06)The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyperproduction ... -
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Perera, U.; Gillett, C.; Law, A-L.; Sharma, V. P.; Wang, J.; e.a. (Springer Nature, 2016-03)Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly of branched F-actin networks. How deregulation of actin regulators ... -
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression
Clauser, Karl R.; Mani, D. R.; Carr, Steven A.; Naba, Alexandra; Hynes, Richard O. (Nature Publishing Group, 2017-01)The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1mm[superscript 3] and are unlikely to disseminate. ... -
Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival
Gocheva, Vasilena; Naba, Alexandra; Bhutkar, Arjun; Guardia, Talia; Miller, Kathryn; e.a. (National Academy of Sciences (U.S.), 2017-06)The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and ... -
Towards definition of an ECM parts list: An advance on GO categories
Naba, Alexandra; Hoersch, Sebastian; Hynes, Richard O.; Hynes, Richard O. (Elsevier B.V., 2012-09)Those of us interested in the extracellular matrix (ECM) are faced with significant challenges of definition. ECM proteins are large, complex and assembled into crosslinked insoluble matrices. This has meant that defining ...