Browsing by Author "Naba, Alexandra"
Now showing items 1-10 of 10
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Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics
Pearce, Oliver M. T.; Del Rosario, Amanda; Ma, Duanduan; Ding, Huiming; Rajeeve, Vinothini; e.a. (American Chemical Society (ACS), 2017-04)The extracellular matrix (ECM) is a complex meshwork of insoluble fibrillar proteins and signaling factors interacting together to provide architectural and instructional cues to the surrounding cells. Alterations in ECM ... -
Comprehensive proteomic characterization of stem cell-derived extracellular matrices
Ragelle, Heloise; Naba, Alexandra; Larson, Benjamin; Zhou, Fangheng; Prijic, Miralem; e.a. (Elsevier BV, 2017-06)In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions ... -
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters
Naba, Alexandra; Clauser, Karl R.; Carr, Steven A.; Lamar, John; Hynes, Richard O (eLife Sciences Publications, Ltd., 2014-03)The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that ... -
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver
Naba, Alexandra; Clauser, Karl R.; Whittaker, Charles A.; Carr, Steven A.; Tanabe, Kenneth K.; e.a. (BioMed Central Ltd., 2014-07)Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis ... -
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
Mak, Hannah; Naba, Alexandra; Varma, Sonal; Schick, Colleen; Day, Andrew; e.a. (BioMed Central Ltd., 2012-03)Background The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our group ... -
Ezrin regulates microvillus morphogenesis by promoting distinct activities of Eps8 proteins
Zwaenepoel, Ingrid; Da, Marcel Menezes Lyra; Maestro, Laurence Del; Formstecher, Etienne; Louvard, Daniel; e.a. (American Society for Cell Biology, 2012-01)The mechanisms that regulate actin filament polymerization resulting in the morphogenesis of the brush border microvilli in epithelial cells remain unknown. Eps8, the prototype of a family of proteins capable of capping ... -
Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations
Barqué, Anna; Jan, Kyleen; De La Fuente, Emanuel; Nicholas, Christina L.; Hynes, Richard O; e.a. (Wiley, 2020-10)Background: The extracellular matrix (ECM) is a fundamental component of multicellular organisms that orchestrates developmental processes and controls cell and tissue organization. We previously identified the novel ECM ... -
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
Naba, Alexandra; Clauser, Karl R.; Hoersch, Sebastian; Liu, Hui; Carr, Steven A; e.a. (American Society for Biochemistry and Molecular Biology, 2011-12)The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing both biophysical and biochemical cues that are important regulators of cell proliferation, survival, differentiation, and migration. ... -
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix
Glavey, S V; Manier, S; Clauser, K; Tahri, S; Park, J; e.a. (Nature Publishing Group, 2017-03)The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions ... -
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches
Hebert, Jess D.; Myers, Samuel A.; Naba, Alexandra; Abbruzzese, Genevieve; Lamar, John M.; e.a. (American Association for Cancer Research (AACR), 2020-02)© 2020 American Association for Cancer Research. Metastasis causes most cancer-related deaths, and one poorly understood aspect of metastatic cancer is the adaptability of cells from a primary tumor to create new niches ...