Browsing by Author "Xavier, Ramnik J."
Now showing items 1-2 of 2
-
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Chen, Sidi; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; e.a. (Elsevier, 2014-09)CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in ... -
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
Avraham, Roi; Brown, Douglas; Penaranda, Cristina; Jijon, Humberto B.; Trombetta, John J.; e.a. (Elsevier, 2015-09)Encounters between immune cells and invading bacteria ultimately determine the course of infection. These interactions are usually measured in populations of cells, masking cell-to-cell variation that may be important for ...